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- Li YD, Wu Y, Zhou TL, Yuan Q, Li GR, Wu WY, Wang Y, Li G. Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis. Biomedicines. 2026 Jan 15;14(1):194. doi: 10.3390/biomedicines14010194.
[摘要]
- Wang H, Peng LJ, Lu W, Li GR, Zhao PT, Lv X, Dong MQ, Liu ML. Acacetin reverses hypoxic pulmonary hypertension by inhibiting hypoxia-induced proliferation of pulmonary artery smooth muscle cells via SIRT1-HMGB1 pathway. Eur J Pharmacol. 2025 Apr 19;998:177650. doi: 10.1016/j.ejphar.2025.177650.
[摘要]
- Wang SY, Wang YJ, Dong MQ, Li GR. Acacetin is a Promising Drug Candidate for Cardiovascular Diseases. Am J Chin Med. 2024:52(6): 1661-1692. doi: 10.1142/S0192415X24500654.
[摘要]
- Lu Y, Wu YW, Pu J, Wu QF, Dong Q, Zhao N, Li GR, Du YM. Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration. Chin Med. 2024;19(1): 68. doi: 10.1186/s13020-024-00943-9. [原文]
[摘要]
- Song F, Mao YJ, Hu Y, Zhao SS, Wang R, Wu WY, Li GR, Wang Y, Li G. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway. Eur J Pharmacol. 2022;922: 174916. doi: 10.1016/j.ejphar.2022.174916. [原文]
[摘要]
- Cui YK, Hong YX, Wu WY, Han WM, Wu Y, Wu C, Li GR, Wang Y. Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1alpha pathway. Eur J Pharmacol. 2022;920: 174858. doi: 10.1016/j.ejphar.2022.174858.
[摘要]
- Hong YX, Wu WY, Song F, Wu C, Li GR, Wang Y. Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy. Aging (Albany NY). 2021;13. doi: 10.18632/aging.203163. [原文]
[摘要]
- Han WM, Chen XC, Li GR, Wang Y. Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals. Front Pharmacol. 2020;11: 607796. doi: 10.3389/fphar.2020.607796. [原文]
[摘要]
- Di Diego JM, Patocskai B, Barajas-Martinez H, Borbáth V, Ackerman MJ, Burashnikov A, Clatot J, Li GR, Robinson VM, Hu D, Antzelevitch C. Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes. PLoS One. 2020 Nov 24;15(11):e0242747. doi: 10.1371/journal.pone.0242747. [原文]
[摘要]
- Wu WY, Cui YK, Hong YX, Li YD, Wu Y, Li G, Li GR, Wang Y. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules. J Cell Mol Med. 2020;24(20): 12141-12153. doi: 10.1111/jcmm.15859. Epub 2020 Sep 11. [原文]
[摘要]
- Wu WY, Li YD, Cui YK, Wu C, Hong YX, Li G, Wu Y, Jie LJ, Wang Y, Li GR. The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2018;9: 497. doi: 10.3389/fphar.2018.00497. eCollection 2018. [原文]
[摘要]
- Chen KH, Liu H, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells. Front Pharmacol. 2017;8: 716. doi: 10.3389/fphar.2017.00716. eCollection 2017. [原文]
[摘要]
- Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016;6: 36435. doi: 10.1038/srep36435. [原文]
[摘要]
- Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016;6: 25743. doi: 10.1038/srep25743. [原文]
[摘要]
- Wu HJ, Sun HY, Wu W, Zhang YH, Qin GW, Li GR. Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels. PLoS One. 2013;8(3): e57864. doi: 10.1371/journal.pone.0057864. [原文]
[摘要]
- Wu HJ, Wu W, Sun HY, Qin GW, Wang HB, Wang PW, Yalamanchili HK, Wang JW, Tse HF, Lau CP, Vanhoutte PM, Li GR. Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. J Mol Cell Cardiol. 2011;51(6): 966-973. doi: 10.1016/j.yjmcc.2011.08.022.
[摘要]
- Li GR, Wang HB, Qin GW, Jin MW, Tang Q, Sun HY, Du XL, Deng XL, Zhang XH, Chen JB, Chen L, Xu XH, Cheng LC, Chiu SW, Tse HF, Vanhoutte PM, Lau CP. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation. 2008;117(19): 2449-57. doi: 10.1161/CIRCULATIONAHA.108.769554. [原文]
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